Background: Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotidepolymorphisms\n(SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim\nof this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and\ntheir associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators\nof insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared\nwith healthy pregnant controls.\nMethods: 80 women with GDM and 80 women with normal pregnancy were considered for the present study.\nGenotyping of selected SNPs in all study subjects was done using the Taq-Man assay and the adipokines and ghrelin\nwere measured by immunoassays. Chi square test, odds ratios (OR) and their respective 95% confidence intervals\nwere used to measure the strength of association between FTO SNPs and GDM.\nResults: There was no association among FTO SNPs and GDM. Interestingly, in GDM group, women carrying the risk\nalleles of the three SNPs had increased TNF-alpha, and decreased adiponectin levels; these associations remained\nsignificant after adjusting for pre-gestational body weight and age. Moreover, the risk allele of rs1421085 was also\nassociated with increased weight gain during pregnancy.\nConclusions: The FTP SNPs rs8050136, rs9939609, and rs1421085 are not a major genetic regulator in the etiology of\nGDM in the studied ethnic group. However, these SNPs were associated with adiponectin and TNF-alpha concentrations\nin GDM subjects.
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